AVROBIO Announces Updated Clinical Data for AVR-RD-01 Gene Therapy in Fabry Disease
First two patients in Phase 1 study continue to demonstrate AGA enzyme activity above the diagnostic range for classic Fabry disease 18 months and six months after receiving AVR-RD-01, respectively; Patient 1 is no longer receiving enzyme replacement therapy
Enrollment continues in Phase 2 clinical trial and first patient’s 3-month results demonstrate AGA enzyme activity from AVR-RD-01 gene therapy in ERT-naïve patient
Company to host a conference call to discuss these additional data today,
The investigator-sponsored Phase 1 study is designed to assess the safety of AVR-RD-01 in up to six patients with Fabry disease who have been treated with standard of care enzyme replacement therapy (ERT) for at least six months prior to receiving AVR-RD-01. The Phase 1 study is conducted by the FACTs team (Fabry disease Clinical research and Therapeutics) in
“We are encouraged by the AGA enzyme activity we are seeing after treatment with AVR-RD-01 in the first two patients with Fabry disease in the Phase 1 study. Both of these patients have AGA activity that remains above the diagnostic range for males with classic Fabry disease, and all patients will continue to be followed for assessment of long-term durable response. We are especially pleased that patient 1 was taken off ERT in mid-July and remains off,” said
Key results from the three patients who have been dosed with AVR-RD-01 in the ongoing Phase 1 clinical study, include:
- Patient 1: At 18 months after AVR-RD-01 treatment, AGA enzyme activity was 2.6 nmol/hr/ml, which is above the diagnostic range for males with classic Fabry disease (defined as less than 1 nmol/hr/ml), and average vector copy number (VCN) in peripheral blood was 0.1. VCN refers to the average number of copies of the lentiviral-vector inserted gene that are integrated into the genome of a cell. Bone marrow aspirate data at 14 months continues to support engraftment of cells that are producing progeny with the vector inserted.
After the 18-month follow-up visit for patient 1, the FACTs team investigators received approval, and the patient consented, to discontinue the regular bi-weekly treatment with ERT. Patient 1 will continue to be monitored to evaluate his AGA enzyme activity following discontinuation of ERT.
- Patient 2: At six months after AVR-RD-01 treatment, AGA enzyme activity (3.7 nmol/hr/ml) also remained above the diagnostic range for males with classic Fabry disease and the VCN was 0.4.
- Patient 3: In
July 2018, the third patient with Fabry disease was dosed with AVR-RD-01 in the Phase 1 study.
- As a Phase 1 study, the primary endpoint of this study is safety. Preliminary safety data from these three subjects indicate AVR-RD-01 was generally well tolerated and no serious adverse events (SAEs) related to AVR-RD-01 have been reported (as of the safety data cut-off date of
August 24, 2018).
- Continued patient enrollment is planned and the protocol has been amended to allow the FACTs team, at their discretion, to discontinue ERT six months after treatment with AVR‑RD-01.
“We particularly highlight the 18-month data from patient 1 who maintained AGA enzyme activity above the diagnostic range for classic Fabry disease and we received approval to discontinue ERT and observe the impact of gene therapy alone,” said Dr.
In the Phase 2, FAB-201 Study, data is reported from the first patient who has been dosed with AVR-RD-01:
- Patient FAB-201-1: Data for the first patient, FAB-201-1, in the Phase 2 trial demonstrated that after three months of treatment with AVR-RD-01, AGA plasma enzyme activity was 2.74 nmol/hr/ml and VCN was 0.5.
Preliminary safety data from patient FAB-201-1 indicate that AVR-RD-01 was generally well tolerated; no SAEs related to AVR-RD-01 have been reported (as of the safety data cut-off date of
Further details of the Phase 2, FAB-201 Study of AVR-RD-01 in Fabry disease are available on clinicaltrials.gov.2
These interim results from the investigator-sponsored Phase 1 study and the
Conference Call and Webcast Information
AVR-RD-01 is an ex vivo lentiviral gene therapy being investigated as a single-dose therapy with the potential to provide durable and life-long potential therapeutic benefit for patients with Fabry disease. AVR-RD-01 is designed to employ a state-of-the-art lentiviral vector platform that is an efficient and proven gene transfer system for the permanent integration of a functional copy of the gene into the patient’s own stem cells. In patients with Fabry disease, hematopoietic stem cells are collected from the patient, and then transduced with lentiviral vector carrying a functional version of the GLA gene that encodes α‑galactosidase A (AGA) – the enzyme that is deficient in Fabry disease – to create AVR-RD-01 gene therapy. AVR-RD-01 is then infused back into the patient with the goal of restoring normal GLA gene expression such that functional AGA enzyme is sufficiently produced by the patient’s own body.
Various express or implied statements in this release concerning AVROBIO’s future expectations, plans and prospects, including without limitation, statements regarding the development and the continued progress of AVROBIO’s programs, and the therapeutic potential of its product candidates, including AVR-RD-01, constitute forward-looking statements for the purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. Any such statements in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Any forward-looking statements in this press release are based on management’s current expectations of future events only as of today and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, the risk that any one or more of AVROBIO’s product candidates, including AVR-RD-01, will not be successfully developed or commercialized, the risk of cessation or delay of any of AVROBIO’s ongoing or planned clinical trials, and the risk that prior results, such as signals of safety, activity or durability of effect, observed from preclinical studies or clinical trials will not be replicated or will not continue in ongoing or future studies or trials involving AVROBIO’s product candidates. For a discussion of these and other risks and uncertainties, and other important factors, any of which could cause AVROBIO’s actual results to differ from those contained in the forward-looking statements, see the section entitled “Risk Factors” in AVROBIO’s Quarterly Report on Form 10-Q for the quarter ended
1 The official name of the ’FAB-201 Study’ is AVRO-RD-01-201, which is a Phase 2 trial of AVROBIO’s investigational gene therapy, AVR-RD-01, in Fabry disease.
2 FAB-201 Study on clinicaltrials.gov: https://clinicaltrials.gov/ct2/results?cond=&term=AVROBIO&cntry=&state=&city=&dist=
Christopher F. Brinzey Westwicke Partners339-970-2843 email@example.com Media Contact: Kathryn MorrisThe Yates Network 914-204-6412 firstname.lastname@example.org
Source: AVROBIO, Inc.